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Hypertrophic non-obstructive cardiomyopathy

MedGen UID:
573727
•Concept ID:
C0340425
•
Disease or Syndrome
Synonyms: HCM - Hypertrophic non-obstructive cardiomyopathy; Hypertrophic cardiomyopathy without obstruction
SNOMED CT: Hypertrophic cardiomyopathy without obstruction (195020003); Hypertrophic non-obstructive cardiomyopathy (195020003); HCM - Hypertrophic non-obstructive cardiomyopathy (195020003)

Professional guidelines

PubMed

Is surgery the gold standard in the treatment of obstructive hypertrophic cardiomyopathy?
Knyshov G, Lazoryshynets V, Rudenko K, Kravchuk B, Beshlyaga V, Zalevsky V, Rasputnyak O, Batsak B
Interact Cardiovasc Thorac Surg 2013 Jan;16(1):5-9. Epub 2012 Sep 30 doi: 10.1093/icvts/ivs352. PMID: 23027595Free PMC Article
Tissue Doppler imaging assessment of long axis left ventricular function in hypertensive patients with concentric left ventricular hypertrophy: differential diagnosis with hypertrophic cardiomyopathy.
Cardim N, Longo S, Ferreira T, Pereira A, Gouveia A, Reis RP, Correia JM
Rev Port Cardiol 2002 Jun;21(6):709-40. PMID: 12194374
Differential diagnosis of hypertrophic cardiomyopathies: typical (subaortic) hypertrophic obstructive cardiomyopathy, atypical (mid-ventricular) hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy.
Kuhn H, Mercier J, Köhler E, Frenzel H, Hort W, Loogen F
Eur Heart J 1983 Nov;4 Suppl F:93-104. doi: 10.1093/eurheartj/4.suppl_f.93. PMID: 6686549

Recent clinical studies

Etiology

Respiratory dyssynchrony is a predictor of prognosis in patients with hypertrophic non-obstructive cardiomyopathy.
Potratz M, Fox H, Rudolph V, Faber L, Dumitrescu D, Bitter T
Int J Cardiol 2021 Jun 1;332:105-112. Epub 2021 Mar 2 doi: 10.1016/j.ijcard.2021.02.077. PMID: 33667581
Circulating levels of insulin-like growth factor-1 and its binding proteins in patients with hypertrophic cardiomyopathy.
Saeki H, Hamada M, Hiwada K
Circ J 2002 Jul;66(7):639-44. doi: 10.1253/circj.66.639. PMID: 12135130
Altered autonomic cardiac control in hypertrophic cardiomyopathy. Role of outflow tract obstruction and myocardial hypertrophy.
Limbruno U, Strata G, Zucchi R, Baglini R, Mengozzi G, Balbarini A, Mariani M
Eur Heart J 1998 Jan;19(1):146-53. doi: 10.1053/euhj.1997.0743. PMID: 9503188
Successful bone marrow transplantation and treatment of BCG infection in two patients with severe combined immunodeficiency.
Heyderman RS, Morgan G, Levinsky RJ, Strobel S
Eur J Pediatr 1991 May;150(7):477-80. doi: 10.1007/BF01958426. PMID: 1915499
Arrhythmias in hypertrophic obstructive and non-obstructive cardiomyopathy.
Borggrefe M, Kuhn H, Königer HH, Stöter H, Breithardt G, Loogen F, Schulte HD, Bircks W
Eur Heart J 1983 Nov;4 Suppl F:245-51. doi: 10.1093/eurheartj/4.suppl_f.245. PMID: 6686542

Diagnosis

Respiratory dyssynchrony is a predictor of prognosis in patients with hypertrophic non-obstructive cardiomyopathy.
Potratz M, Fox H, Rudolph V, Faber L, Dumitrescu D, Bitter T
Int J Cardiol 2021 Jun 1;332:105-112. Epub 2021 Mar 2 doi: 10.1016/j.ijcard.2021.02.077. PMID: 33667581
Primary antiphospholipid syndrome, hypertrophic non-obstructive cardiomyopathy and hypotelorism.
Kellermair J, Kammler J, Laubichler P, Steinwender C
BMJ Case Rep 2016 Apr 5;2016 doi: 10.1136/bcr-2016-214765. PMID: 27048398Free PMC Article
Fabry disease in patients with hypertrophic cardiomyopathy (HCM).
Beer G, Reinecke P, Gabbert HE, Hort W, Kuhn H
Z Kardiol 2002 Dec;91(12):992-1002. doi: 10.1007/s00392-002-0870-7. PMID: 12490989
Differential diagnosis of hypertrophic cardiomyopathies: typical (subaortic) hypertrophic obstructive cardiomyopathy, atypical (mid-ventricular) hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy.
Kuhn H, Mercier J, Köhler E, Frenzel H, Hort W, Loogen F
Eur Heart J 1983 Nov;4 Suppl F:93-104. doi: 10.1093/eurheartj/4.suppl_f.93. PMID: 6686549
Severe congestive heart failure in mild pulmonic stenosis due to dysplastic pulmonary valve associated with cardiomyopathy.
Schneeweiss A, Shem-Tov A, Hegesh J, Blieden LC, Feigel A, Neufeld HN
Eur Heart J 1983 Apr;4(4):286-8. doi: 10.1093/oxfordjournals.eurheartj.a061461. PMID: 6224694

Therapy

Fabry disease in patients with hypertrophic cardiomyopathy (HCM).
Beer G, Reinecke P, Gabbert HE, Hort W, Kuhn H
Z Kardiol 2002 Dec;91(12):992-1002. doi: 10.1007/s00392-002-0870-7. PMID: 12490989
Successful bone marrow transplantation and treatment of BCG infection in two patients with severe combined immunodeficiency.
Heyderman RS, Morgan G, Levinsky RJ, Strobel S
Eur J Pediatr 1991 May;150(7):477-80. doi: 10.1007/BF01958426. PMID: 1915499
Hemodynamic long-term results after medical and surgical therapy of hypertrophic cardiomyopathies.
Lösse B, Loogen F, Schulte HD
Z Kardiol 1987;76 Suppl 3:119-30. PMID: 3433864
Exercise performance in hypertrophic cardiomyopathies.
Lösse B, Kuhn H, Loogen F, Schulte HD
Eur Heart J 1983 Nov;4 Suppl F:197-208. doi: 10.1093/eurheartj/4.suppl_f.197. PMID: 6686536
Severe congestive heart failure in mild pulmonic stenosis due to dysplastic pulmonary valve associated with cardiomyopathy.
Schneeweiss A, Shem-Tov A, Hegesh J, Blieden LC, Feigel A, Neufeld HN
Eur Heart J 1983 Apr;4(4):286-8. doi: 10.1093/oxfordjournals.eurheartj.a061461. PMID: 6224694

Prognosis

Respiratory dyssynchrony is a predictor of prognosis in patients with hypertrophic non-obstructive cardiomyopathy.
Potratz M, Fox H, Rudolph V, Faber L, Dumitrescu D, Bitter T
Int J Cardiol 2021 Jun 1;332:105-112. Epub 2021 Mar 2 doi: 10.1016/j.ijcard.2021.02.077. PMID: 33667581
Failure to raise blood pressure during exercise is a poor prognostic sign in patients with hypertrophic non-obstructive cardiomyopathy.
Isobe N, Toyama T, Taniguchi K, Oshima S, Kubota S, Suzuki T, Nagaoka H, Adachi H, Naito S, Hoshizaki H
Circ J 2003 Mar;67(3):191-4. doi: 10.1253/circj.67.191. PMID: 12604864
Differential diagnosis of hypertrophic cardiomyopathies: typical (subaortic) hypertrophic obstructive cardiomyopathy, atypical (mid-ventricular) hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy.
Kuhn H, Mercier J, Köhler E, Frenzel H, Hort W, Loogen F
Eur Heart J 1983 Nov;4 Suppl F:93-104. doi: 10.1093/eurheartj/4.suppl_f.93. PMID: 6686549
Arrhythmias in hypertrophic obstructive and non-obstructive cardiomyopathy.
Borggrefe M, Kuhn H, Königer HH, Stöter H, Breithardt G, Loogen F, Schulte HD, Bircks W
Eur Heart J 1983 Nov;4 Suppl F:245-51. doi: 10.1093/eurheartj/4.suppl_f.245. PMID: 6686542
Clinical course and prognosis of patients with typical and atypical hypertrophic obstructive and with hypertrophic non-obstructive cardiomyopathy.
Loogen F, Kuhn H, Gietzen F, Lösse B, Schulte HD, Bircks W
Eur Heart J 1983 Nov;4 Suppl F:145-53. doi: 10.1093/eurheartj/4.suppl_f.145. PMID: 6686530

Clinical prediction guides

Respiratory dyssynchrony is a predictor of prognosis in patients with hypertrophic non-obstructive cardiomyopathy.
Potratz M, Fox H, Rudolph V, Faber L, Dumitrescu D, Bitter T
Int J Cardiol 2021 Jun 1;332:105-112. Epub 2021 Mar 2 doi: 10.1016/j.ijcard.2021.02.077. PMID: 33667581
Evaluation of myocardial glucose metabolism in hypertrophic cardiomyopathy using 18F-fluorodeoxyglucose positron emission tomography.
Aoyama R, Takano H, Kobayashi Y, Kitamura M, Asai K, Amano Y, Kumita SI, Shimizu W
PLoS One 2017;12(11):e0188479. Epub 2017 Nov 27 doi: 10.1371/journal.pone.0188479. PMID: 29176885Free PMC Article
Altered autonomic cardiac control in hypertrophic cardiomyopathy. Role of outflow tract obstruction and myocardial hypertrophy.
Limbruno U, Strata G, Zucchi R, Baglini R, Mengozzi G, Balbarini A, Mariani M
Eur Heart J 1998 Jan;19(1):146-53. doi: 10.1053/euhj.1997.0743. PMID: 9503188
Differential diagnosis of hypertrophic cardiomyopathies: typical (subaortic) hypertrophic obstructive cardiomyopathy, atypical (mid-ventricular) hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy.
Kuhn H, Mercier J, Köhler E, Frenzel H, Hort W, Loogen F
Eur Heart J 1983 Nov;4 Suppl F:93-104. doi: 10.1093/eurheartj/4.suppl_f.93. PMID: 6686549
Hypertrophic non-obstructive cardiomyopathy caused by disorder of the myofiber texture.
Knieriem HJ, Stroobandt R, Meyer H, Bourgeois M
Virchows Arch A Pathol Anat Histol 1975 Aug 12;367(3):209-18. doi: 10.1007/BF00430708. PMID: 125951

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